FIELD: chemistry, pharmaceuticals.
SUBSTANCE: invention pertains to organic synthesis, and particularly to the method of obtaining 2-ethyl-3,5-dimethylpyridine, which can be used in synthesis of corrosion inhibitors as well as medicinal preparations. The method is based on reaction of a liquid phase condensation of propionic aldehyde with a saturated water solution of urea in the presence of palladium dibenzylideneacetone catalyst (Pd(dba)2), taken in molar ratios of aldehyde: urea: catalyst = 20:(14-18):(0.2-0.4) at 150°C for a period of 6-10 hours. 2-ethyl-3,5-dimethylpyridine (1) is obtained with output of 44-58%.
EFFECT: method differs from known methods on the high output of the target product, gentler reaction conditions and high selectivity of the process.
1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR OBTAINING 2-ETHYL-3,5-DIMETHYL PYRIDINE | 2016 |
|
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| METHOD FOR OBTAINING 2-ETHYL-3,5-DIMETHYL PYRIDINE | 2016 |
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