NOVEL COMPOSITIONS CONTAINING QUINOLINE COMPOUNDS Russian patent published in 2008 - IPC C07D215/56 C07D215/22 A61K31/47 A61P37/00 A61P29/00 

FIELD: chemistry.

SUBSTANCE: in novel crystalline salt of formula (II) n represents whole number 2 or 3; Aⁿ⁺ represents polyvalent cation of metal, selected from Mg²⁺, Ca²⁺, Mn²⁺, Cu²⁺, Zn²⁺, Al³⁺ and Fe³⁺; R represents linear or branched C₁-C₄-alkyl or -alkenyl or cyclic C₃-C₄-alkyl; R5 represents linear or branched, saturated or unsaturated C₁-C₄-alkyl or alkenyl, cyclic C₃-C₄-alkyl, linear or branched C₁-C₄-alkylthio, cyclic C₃-C₄-alkylthio, linear or branched C₁-C₄-alkylculfinyl, cyclic C₃-C₄ alkylsulfinyl, fluoro-, chlor-, brom-, trifluoromethyl or trifluoromethoxy; and R6 represents hydrogen; or R5 and R6 together represent methylenedioxy; R' represents hydrogen, linear or branched, saturated or unsaturated C₁-C₄-alkyl or alkenyl, cyclic C₃-C₄-alkyl, linear or branched C₁-C₄-alkoxy, cyclic C₃-C₄-alkoxy, fluoro-, chlor-, brom-, trifluoromethyl; and R" represents hydrogen, fluoro-or chlor- on condition that R" represents fluoro- or chlor- only in case, if R' represents fluoro- or chlor-. Invention also relates to stable solid pharmaceutical composition, methods of stabilisation of salt of formula (II), as well as to method of obtaining crystalline salt of formula (II).

EFFECT: increased stability of novel crystalline salt.

18 cl, 12 ex, 4 tbl