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IPC

G09B23/28(2006-01-01)

A61K33/00(2006-01-01)

A61P9/08(2006-01-01)

(21) (22)

Application

2012108000/14, 2012-03-01

(24)

Start date

2012-03-01

(22)

Actual filing date

2012-03-01

(45)

Published

2013-04-20

(72)

Inventor

Pokrovskij Mikhail VladimirovichStarosel'Tseva Ol'Ga AlekseevnaPokrovskaja Tat'Jana Grigor'EvnaGureev Vladimir VladimirovichKorokin Mikhail ViktorovichGudyrev Oleg SergeevichAlekhin Sergej AleksandrovichChernomortseva Elena StanislavovnaKolesnik Inga MikhajlovnaArustamova Anna Aleksandrovna

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii

METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF HELIUM AND OXYGEN IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY Russian patent published in 2013 - IPC G09B23/28 A61K33/00 A61P9/08

Abstract RU 2479873 C1

FIELD: medicine.

SUBSTANCE: endothelial dysfunction is experimentally simulated in male white Wistar rats by daily intraperitoneal introduction of the endothelial synthetase inhibitor L-nitro-L-arginine-methyl ester 25 mg/kg for 7 days A degree of dysfunction development is estimated by the relation of endothelium-dependent and endothelial-independent vasodilation. Endothelial dysfunction is corrected by daily inhalations of mixed helium and oxygen in the amount of 150 ml and 50 ml respectively, for 7 days.

EFFECT: method provides evident endothelial dysfunction correction.

1 ex, 2 tbl

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RU 2 479 873 C1

Authors

Pokrovskij Mikhail Vladimirovich

Starosel'Tseva Ol'Ga Alekseevna

Pokrovskaja Tat'Jana Grigor'Evna

Gureev Vladimir Vladimirovich

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Alekhin Sergej Aleksandrovich

Chernomortseva Elena Stanislavovna

Kolesnik Inga Mikhajlovna

Arustamova Anna Aleksandrovna

Dates

2013-04-20—Published

2012-03-01—Filed