FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to experimental cardiopharmacology and can be used for correction of endothelial dysfunction that is ensured by simulation of endothelial dysfunction in experiment by daily intraperitoneal introduction to Wistar male rats N-nitro-L-apramiH methyl ester in a dose 25 mg/kg within 7 days. Correction of the dysfunction is enabled by intragastric introduction of Lamotrigine in a dose 8.5 mg/kg once a day.
EFFECT: method ensures possibility for correcting the endothelial dysfunction with antiepileptic agent Lamotrigine previously unknown as such.
2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364393C1 |
| METHOD OF ACETYLSALICYLIC ACID BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364392C1 |
| METHOD OF CLOPIDOGREL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364394C1 |
| METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF TRIMETAZIDINE AND L-ARGININE IN L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY | 2009 |
|
RU2421822C2 |
| METHOD OF TADALAFIL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364395C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH SOLVENT MIXTURE OF HOMEOPATHIC DILUTIONS OF POLYCLONAL RABBIT ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE C12, C30, C200 | 2006 |
|
RU2306953C1 |
| METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION BY PHOSPHOGLIV PREPARATION AT L-NAME INDUCED DEFICIENCY OF NITROGEN OXIDE | 2008 |
|
RU2359668C1 |
| METHOD FOR RECOMBINANT ERYTHROPOIETIN CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2009 |
|
RU2409873C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH PREPARATION PHOSPHOGLIV LYOPHILIZATE IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2008 |
|
RU2372078C1 |
| METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOZARTAN AND RAZVERATROL IN CASES OF LONAME-INDUCED NITROGEN MONOXIDE DEFICIENCY | 2005 |
|
RU2306924C1 |
