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2 369 390

(13)

C1

(51)

IPC

A61K31/401(2006-01-01)

A61P19/10(2006-01-01)

G09B23/28(2006-01-01)

(21) (22)

Application

2008122134/14, 2008-06-02

(24)

Start date

2008-06-02

(22)

Actual filing date

2008-06-02

(45)

Published

2009-10-10

(72)

Inventor

Pokrovskij Mikhail VladimirovichGudyrev Oleg SergeevichFajtel'Son Aleksandr VladimirovichDubrovin Grigorij MendelevichArtjushkova Elena BorisovnaPokrovskaja Tat'Jana Grigor'EvnaKorokin Mikhail ViktorovichBelous Aleksandr SergeevichKochkarov Vladimir IskhakovichDanilenko Ljudmila MikhajlovnaGladchenko Mikhail PetrovichGureev Vladimir VladimirovichKoklina Natal'Ja Jur'Evna

(73)

Holder

Pokrovskij Mikhail VladimirovichGudyrev Oleg SergeevichFajtel'Son Aleksandr Vladimirovich

METHOD OF OSTEOPOROSIS CORRECTION AND PREVENTION OF OSTEOPOROTIC FRACTURE BY MEANS OF ENALAPRILS Russian patent published in 2009 - IPC A61K31/401 A61P19/10 G09B23/28 

Abstract RU 2369390 C1

FIELD: medicine.

SUBSTANCE: to correct osteoporosis and prevent osteoporotic fractures osteoporosis shall be simulated by means of bilateral ovariotomy. Then female Wistar rats are intragastically fed with enalapril of 0.5 mg/kg once a day every day within 8 weeks after ovariotomy. Osteoprotective enalapril action is estimated with respect to microcirculation in bone tissue and width of trabecula of bone.

EFFECT: osteoporosis retardation under hypoestrogenic condition, prevention of osteoporotic fractures owing to increased bone tissue perfusion.

1 tbl, 1 ex

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RU 2 369 390 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gudyrev Oleg Sergeevich

Fajtel'Son Aleksandr Vladimirovich

Dubrovin Grigorij Mendelevich

Artjushkova Elena Borisovna

Pokrovskaja Tat'Jana Grigor'Evna

Korokin Mikhail Viktorovich

Belous Aleksandr Sergeevich

Kochkarov Vladimir Iskhakovich

Danilenko Ljudmila Mikhajlovna

Gladchenko Mikhail Petrovich

Gureev Vladimir Vladimirovich

Koklina Natal'Ja Jur'Evna

Dates

2009-10-10—Published

2008-06-02—Filed

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