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IPC

A61K31/198(2006-01-01)

A61K31/401(2006-01-01)

A61P19/10(2006-01-01)

(21) (22)

Application

2013143106/15, 2013-09-23

(24)

Start date

2013-09-23

(22)

Actual filing date

2013-09-23

(45)

Published

2015-02-20

(72)

Inventor

Gudyrev Oleg SergeevichRadzhkumar Densing Samuehl RadzhFajtel'Son Aleksandr VladimirovichPokrovskij Mikhail VladimirovichRemizov Pavel PavlovichSobolev Mikhail SergeevichPokrovskaja Tat'Jana Grigor'EvnaKorokin Mikhail ViktorovichKochkarov Vladimir IskhakovichArustamova Anna AleksandrovnaChuev Vladimir PetrovichVanjan Aleksandr ShotaevichKhoshchenko Jurij AleksandrovichGrigorenko Aleksandr Petrovich

(73)

Holder

Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"

METHOD FOR CORRECTING BONE MICROCIRCULATION ACCOMPANYING EXPERIMENTALOSTEOPOROSIS AND UNDERLYING FRACTURES WITH USE OF COMBINATION OF L-ARGININE AND ENALAPRIL Russian patent published in 2015 - IPC A61K31/198 A61K31/401 A61P19/10 

Abstract RU 2542424 C1

FIELD: medicine.

SUBSTANCE: method involves simulating osteoporosis in female Wistar rats by a bilateral ovariectomy, and osteoporotic fractures, performing a pharmacological correction of pathological conditions by a combination of L-arginine 200mg/kg and enalapril 0.5mg/kg administered intragastrically daily, as a single dose once a day.

EFFECT: using the declared invention provides the synergetic action consisting in the positive effect on the bone microcirculation in osteoporosis and in an osteotylus in osteoporotic fractures.

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RU 2 542 424 C1

Authors

Gudyrev Oleg Sergeevich

Radzhkumar Densing Samuehl Radzh

Fajtel'Son Aleksandr Vladimirovich

Pokrovskij Mikhail Vladimirovich

Remizov Pavel Pavlovich

Sobolev Mikhail Sergeevich

Pokrovskaja Tat'Jana Grigor'Evna

Korokin Mikhail Viktorovich

Kochkarov Vladimir Iskhakovich

Arustamova Anna Aleksandrovna

Chuev Vladimir Petrovich

Vanjan Aleksandr Shotaevich

Khoshchenko Jurij Aleksandrovich

Grigorenko Aleksandr Petrovich

Dates

2015-02-20—Published

2013-09-23—Filed

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