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2 775 439

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IPC

A61K31/4425(2006-01-01)

A61P19/10(2006-01-01)

G09B23/28(2006-01-01)

(21) (22)

Application

2021137147, 2021-12-15

(24)

Start date

2021-12-15

(22)

Actual filing date

2021-12-15

(45)

Published

2022-06-30

(72)

Inventor

Trunov Konstantin SergeevichSkachilova Sofiya YakovlevnaGudyrev Oleg SergeevichDanilenko Lyudmila MikhajlovnaPokrovskij Mikhail VladimirovichSimakina Ekaterina AleksandrovnaDanilenko Anton PavlovichShilova Elena VladimirovnaStefanova Marina SergeevnaYakushev Vladimir IvanovichGureev Vladimir VladimirovichMartynova Olga Viktorovna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR CORRECTING OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES WITH 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINIUM HYDROXYBUTANEDIOATE IN EXPERIMENT Russian patent published in 2022 - IPC A61K31/4425 A61P19/10 G09B23/28

Abstract RU 2775439 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, the field of experimental pharmacology. A method for correcting osteoporosis and osteoporotic fractures in the experiment includes modeling osteoporosis using bilateral oophorectomy and osteoporotic fractures of the femur in female Wistar rats. As a means of correction, the compound 2-ethyl-6-methyl-3-hydroxypyridinium hydroxybutanedioate is used at a dose of 2 mg/kg, which is administered daily intragastrically to a laboratory animal once a day, against the background of modeling osteoporosis for eight weeks, and for fractures - against the background of modeling osteoporosis for twelve weeks.

EFFECT: invention provides effective prevention of a drop in the level of microcirculation in the proximal femoral metaphysis, slowing down the development of osteoporosis in a hypoestrogenic state, creating favorable conditions for successful consolidation of fractures.

1 cl, 1 ex, 2 tbl

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RU 2 775 439 C1

Authors

Trunov Konstantin Sergeevich

Skachilova Sofiya Yakovlevna

Gudyrev Oleg Sergeevich

Danilenko Lyudmila Mikhajlovna

Pokrovskij Mikhail Vladimirovich

Simakina Ekaterina Aleksandrovna

Danilenko Anton Pavlovich

Shilova Elena Vladimirovna

Stefanova Marina Sergeevna

Yakushev Vladimir Ivanovich

Gureev Vladimir Vladimirovich

Martynova Olga Viktorovna

Dates

2022-06-30—Published

2021-12-15—Filed