METHOD FOR CORRECTION OF BONE TISSUE MICROCIRCULATON IN EXPERIMENTAL OSTEOPOROSIS AND ASSOCIATED FRACTURES WITH COMBINATION OF RECOMBINANT ERYTHROPOIETIN AND ROSUVASTATIN Russian patent published in 2015 - IPC A61K31/47 A61K31/18 A61K31/185 A61K31/505 A61K38/18 A61P19/10 G09B23/28 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to experimental pharmacology and represents a method for correction of bone tissue microcirculation in experimental osteoporosis and associated fractures, involving administering a combination of pharmacological agents into a laboratory animals after simulating osteoporosis by a bilateral ovariectomy and osteoporotic femoral fractures in Wistar rats, differing by the fact that the above agents are presented by a combination of recombinant erythropoietin in a single sub-erythrostimulating dose of 50 international units/kg administered into the laboratory animal subcutaneously once a day every week, and rosuvastatin in a dose of 0.86 mg/kg, which is administered intragastrically daily into the laboratory animal once a day with underlying simulating osteoporosis for eight weeks, and in associated fractures - for twelve weeks.

EFFECT: invention provides the synergism on the positive effect on the bone tissue microcirculation.

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