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2 369 391

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C1

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IPC

A61K31/4178(2006-01-01)

A61P19/10(2006-01-01)

G09B23/08(2006-01-01)

(21) (22)

Application

2008122136/14, 2008-06-02

(24)

Start date

2008-06-02

(22)

Actual filing date

2008-06-02

(45)

Published

2009-10-10

(72)

Inventor

Pokrovskij Mikhail VladimirovichGudyrev Oleg SergeevichFajtel'Son Aleksandr VladimirovichDubrovin Grigorij MendelevichArtjushkova Elena BorisovnaPokrovskaja Tat'Jana Grigor'EvnaKorokin Mikhail ViktorovichBelous Aleksandr SergeevichKochkarov Vladimir IskhakovichDanilenko Ljudmila MikhajlovnaGladchenko Mikhail PetrovichGureev Vladimir VladimirovichKoklina Natal'Ja Jur'Evna

(73)

Holder

Pokrovskij Mikhail VladimirovichGudyrev Oleg SergeevichFajtel'Son Aleksandr Vladimirovich

METHOD OF OSTEOPOROSIS CORRECTION AND PREVENTION OF OSTEOPOROTIC FRACTURES BY MEANS OF LOSARTAN Russian patent published in 2009 - IPC A61K31/4178 A61P19/10 G09B23/08 

Abstract RU 2369391 C1

FIELD: medicine.

SUBSTANCE: to correct osteoporosis and prevent osteoporotic fractures osteoporosis in female Wistar rats is simulated by means of bilateral ovariotomy. Then the said rats are intragastically fed with losartan of 6 mg/kg once a day every day within 8 weeks after ovariotomy. Osteoprotective losartan action is estimated with respect to microcirculation in bone tissue and width of trabecula of bone.

EFFECT: prevention of osteoparotic fractures after ovariotomy by blocking Angiotensin II Receptor, improved intraosseous microcirculation.

1 tbl, 1 ex

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RU 2 369 391 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gudyrev Oleg Sergeevich

Fajtel'Son Aleksandr Vladimirovich

Dubrovin Grigorij Mendelevich

Artjushkova Elena Borisovna

Pokrovskaja Tat'Jana Grigor'Evna

Korokin Mikhail Viktorovich

Belous Aleksandr Sergeevich

Kochkarov Vladimir Iskhakovich

Danilenko Ljudmila Mikhajlovna

Gladchenko Mikhail Petrovich

Gureev Vladimir Vladimirovich

Koklina Natal'Ja Jur'Evna

Dates

2009-10-10—Published

2008-06-02—Filed

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