Patenton — panteon of patents

(19)

RU

(11)

2 437 160

(13)

C1

(51)

IPC

G09B23/28(2006-01-01)

A61K31/45(2006-01-01)

A61K31/401(2006-01-01)

A61P19/10(2006-01-01)

(21) (22)

Application

2010114475/14, 2010-04-12

(24)

Start date

2010-04-12

(22)

Actual filing date

2010-04-12

(45)

Published

2011-12-20

(72)

Inventor

Pokrovskij Mikhail VladimirovichGudyrev Oleg SergeevichFajtel'Son Aleksandr VladimirovichKoklina Natal'Ja Jur'EvnaArtjushkova Elena BorisovnaPokrovskaja Tat'Jana Grigor'EvnaKorokin Mikhail ViktorovichKorokina Lilija ViktorovnaBelous Aleksandr SergeevichKochkarov Vladimir IskhakovichDanilenko Ljudmila MikhajlovnaGladchenko Mikhail PetrovichGureev Vladimir VladimirovichKolesnik Inga MikhajlovnaStabrovskaja Nadezhda VladimirovnaRagulina Vera AlekseevnaIvanov Aleksandr ViktorovichJakushev Vladimir Ivanovich

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju"

METHOD FOR RESERVATROL AND ENALAPRIL BASED OSTEOPOROSIS CORRECTION AND FRAGILITY FRACTURE PREVENTION Russian patent published in 2011 - IPC G09B23/28 A61K31/45 A61K31/401 A61P19/10 

Abstract RU 2437160 C1

FIELD: medicine.

SUBSTANCE: efficacy is studied in female Wistar rats. Osteoporosis is simulated by bilateral ovariectomy. Osteoporosis is corrected by intraperitoneal introduction of reservatrol 2 mg/kg and intragastric introduction of enalapril 0.5 mg/kg daily once a day for eight weeks after ovariectomy. Osteoprotective action of reservatrol combined with enalapril is estimated by a bone tissue microcirculation level and width of trabeculas of bone.

EFFECT: improved blood circulation and microarchitectonics of bone tissue in hypoestrogen condition.

1 tbl, 2 ex

Similar patents RU2437160C1

Title Year Author Number
METHOD FOR CORRECTING BONE MICROCIRCULATION ACCOMPANYING EXPERIMENTALOSTEOPOROSIS AND UNDERLYING FRACTURES WITH USE OF COMBINATION OF L-ARGININE AND ENALAPRIL 2013
  • Gudyrev Oleg Sergeevich
  • Radzhkumar Densing Samuehl Radzh
  • Fajtel'Son Aleksandr Vladimirovich
  • Pokrovskij Mikhail Vladimirovich
  • Remizov Pavel Pavlovich
  • Sobolev Mikhail Sergeevich
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Korokin Mikhail Viktorovich
  • Kochkarov Vladimir Iskhakovich
  • Arustamova Anna Aleksandrovna
  • Chuev Vladimir Petrovich
  • Vanjan Aleksandr Shotaevich
  • Khoshchenko Jurij Aleksandrovich
  • Grigorenko Aleksandr Petrovich
 RU2542424C1
METHOD FOR THE CORRECTION OF OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES WITH 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN EXPERIMENT 2021
  • Trunov Konstantin Sergeevich
  • Skachilova Sofiya Yakovlevna
  • Gudyrev Oleg Sergeevich
  • Danilenko Lyudmila Mikhajlovna
  • Pokrovskij Mikhail Vladimirovich
  • Simakina Ekaterina Aleksandrovna
  • Danilenko Anton Pavlovich
  • Shilova Elena Vladimirovna
  • Stefanova Marina Sergeevna
  • Yakushev Vladimir Ivanovich
  • Gureev Vladimir Vladimirovich
  • Martynova Olga Viktorovna
 RU2763011C1
METHOD OF CORRECTING MICROCIRCULATION IN BONE TISSUE WITH COMBINATION OF L-NORVALIN AND ROSUVASTATIN IN CASE OF EXPERIMENTAL OSTEOPOROSIS AND FRACTURES AT ITS BACKGROUND 2013
  • Gudyrev Oleg Sergeevich
  • Radzhkumar Densing Samuehl Radzh
  • Fajtel'Son Aleksandr Vladimirovich
  • Pokrovskij Mikhail Vladimirovich
  • Remizov Pavel Pavlovich
  • Sobolev Mikhail Sergeevich
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Korokin Mikhail Viktorovich
  • Kochkarov Vladimir Iskhakovich
  • Arustamova Anna Aleksandrovna
  • Vanjan Aleksandr Shotaevich
  • Protsenko Roman Viktorovich
  • Khoshchenko Jurij Aleksandrovich
  • Grigorenko Aleksandr Petrovich
 RU2540927C1
METHOD FOR CORRECTION OF BONE TISSUE MICROCIRCULATON IN EXPERIMENTAL OSTEOPOROSIS AND ASSOCIATED FRACTURES WITH COMBINATION OF RECOMBINANT ERYTHROPOIETIN AND ROSUVASTATIN 2013
  • Gudyrev Oleg Sergeevich
  • Remizov Pavel Pavlovich
  • Sobolev Mikhail Sergeevich
  • Fajtel'Son Aleksandr Vladimirovich
  • Pokrovskij Mikhail Vladimirovich
  • Radzhkumar Densing Samuehl Radzh
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Korokin Mikhail Viktorovich
  • Kochkarov Vladimir Iskhakovich
  • Arustamova Anna Aleksandrovna
 RU2541184C1
METHOD OF OSTEOPOROSIS CORRECTION AND PREVENTION OF OSTEOPOROTIC FRACTURE BY MEANS OF ENALAPRILS 2008
  • Pokrovskij Mikhail Vladimirovich
  • Gudyrev Oleg Sergeevich
  • Fajtel'Son Aleksandr Vladimirovich
  • Dubrovin Grigorij Mendelevich
  • Artjushkova Elena Borisovna
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Korokin Mikhail Viktorovich
  • Belous Aleksandr Sergeevich
  • Kochkarov Vladimir Iskhakovich
  • Danilenko Ljudmila Mikhajlovna
  • Gladchenko Mikhail Petrovich
  • Gureev Vladimir Vladimirovich
  • Koklina Natal'Ja Jur'Evna
 RU2369390C1
METHOD FOR CORRECTING BONE MICROCIRCULATION ACCOMPANYING OSTEOPOROSIS AND UNDERLYING FRACTURES WITH USE OF COMBINATION OF L-ARGININE AND LOSARTAN 2013
  • Gudyrev Oleg Sergeevich
  • Radzhkumar Densing Samuehl Radzh
  • Fajtel'Son Aleksandr Vladimirovich
  • Pokrovskij Mikhail Vladimirovich
  • Remizov Pavel Pavlovich
  • Sobolev Mikhail Sergeevich
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Korokin Mikhail Viktorovich
  • Kochkarov Vladimir Iskhakovich
  • Arustamova Anna Aleksandrovna
 RU2542425C1
METHOD FOR CORRECTING OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES WITH 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINIUM HYDROXYBUTANEDIOATE IN EXPERIMENT 2021
  • Trunov Konstantin Sergeevich
  • Skachilova Sofiya Yakovlevna
  • Gudyrev Oleg Sergeevich
  • Danilenko Lyudmila Mikhajlovna
  • Pokrovskij Mikhail Vladimirovich
  • Simakina Ekaterina Aleksandrovna
  • Danilenko Anton Pavlovich
  • Shilova Elena Vladimirovna
  • Stefanova Marina Sergeevna
  • Yakushev Vladimir Ivanovich
  • Gureev Vladimir Vladimirovich
  • Martynova Olga Viktorovna
 RU2775439C1
METHOD FOR RESERVATROL-BASED OSTEOPOROSIS CORRECTION AND FRAGILITY FRACTURE PREVENTION 2010
  • Pokrovskij Mikhail Vladimirovich
  • Gudyrev Oleg Sergeevich
  • Fajtel'Son Aleksandr Vladimirovich
  • Koklina Natal'Ja Jur'Evna
  • Artjushkova Elena Borisovna
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Korokin Mikhail Viktorovich
  • Korokina Lilija Viktorovna
  • Belous Aleksandr Sergeevich
  • Kochkarov Vladimir Iskhakovich
  • Danilenko Ljudmila Mikhajlovna
  • Gladchenko Mikhail Petrovich
  • Gureev Vladimir Vladimirovich
  • Kolesnik Inga Mikhajlovna
  • Stabrovskaja Nadezhda Vladimirovna
  • Ragulina Vera Alekseevna
  • Ivanov Aleksandr Viktorovich
  • Jakushev Vladimir Ivanovich
 RU2437161C1
METHOD FOR ROSUVASTATIN CORRECTION OF BONE MICROCIRCULATION IN EXPERIMENTAL OSTEOPOROSIS AND ACCOMPANYING FRACTURES 2013
  • Gudyrev Oleg Sergeevich
  • Remizov Pavel Pavlovich
  • Sobolev Mikhail Sergeevich
  • Fajtel'Son Aleksandr Vladimirovich
  • Pokrovskij Mikhail Vladimirovich
  • Radzhkumar Densing Samuehl Radzh
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Korokin Mikhail Viktorovich
  • Kochkarov Vladimir Iskhakovich
  • Arustamova Anna Aleksandrovna
 RU2538612C1
METHOD FOR RECOMBINANT ERYTHROIETIN CORRECTION OF BONE TISSUE MICROCIRCULATION ACCOMPANYING SIMULATED OSTEOPOROSIS AND ASSOCIATED FRACTURES 2013
  • Gudyrev Oleg Sergeevich
  • Remizov Pavel Pavlovich
  • Sobolev Mikhail Sergeevich
  • Fajtel'Son Aleksandr Vladimirovich
  • Pokrovskij Mikhail Vladimirovich
  • Radzhkumar Densing Samuehl Radzh
  • Pokrovskaja Tat'Jana Grigor'Evna
  • Korokin Mikhail Viktorovich
  • Kochkarov Vladimir Iskhakovich
  • Arustamova Anna Aleksandrovna
  • Narykov Roman Aleksandrovich
  • Avtina Tat'Jana Valer'Evna
  • Zatolokina Marija Alekseevna
 RU2541181C1

RU 2 437 160 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gudyrev Oleg Sergeevich

Fajtel'Son Aleksandr Vladimirovich

Koklina Natal'Ja Jur'Evna

Artjushkova Elena Borisovna

Pokrovskaja Tat'Jana Grigor'Evna

Korokin Mikhail Viktorovich

Korokina Lilija Viktorovna

Belous Aleksandr Sergeevich

Kochkarov Vladimir Iskhakovich

Danilenko Ljudmila Mikhajlovna

Gladchenko Mikhail Petrovich

Gureev Vladimir Vladimirovich

Kolesnik Inga Mikhajlovna

Stabrovskaja Nadezhda Vladimirovna

Ragulina Vera Alekseevna

Ivanov Aleksandr Viktorovich

Jakushev Vladimir Ivanovich

Dates

2011-12-20—Published

2010-04-12—Filed

download Download PDF read Similar patents