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IPC

G09B23/28(2006-01-01)

A61K31/45(2006-01-01)

A61P19/10(2006-01-01)

(21) (22)

Application

2010114473/14, 2010-04-12

(24)

Start date

2010-04-12

(22)

Actual filing date

2010-04-12

(45)

Published

2011-12-20

(72)

Inventor

Pokrovskij Mikhail VladimirovichGudyrev Oleg SergeevichFajtel'Son Aleksandr VladimirovichKoklina Natal'Ja Jur'EvnaArtjushkova Elena BorisovnaPokrovskaja Tat'Jana Grigor'EvnaKorokin Mikhail ViktorovichKorokina Lilija ViktorovnaBelous Aleksandr SergeevichKochkarov Vladimir IskhakovichDanilenko Ljudmila MikhajlovnaGladchenko Mikhail PetrovichGureev Vladimir VladimirovichKolesnik Inga MikhajlovnaStabrovskaja Nadezhda VladimirovnaRagulina Vera AlekseevnaIvanov Aleksandr ViktorovichJakushev Vladimir Ivanovich

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju"

METHOD FOR RESERVATROL-BASED OSTEOPOROSIS CORRECTION AND FRAGILITY FRACTURE PREVENTION Russian patent published in 2011 - IPC G09B23/28 A61K31/45 A61P19/10

Abstract RU 2437161 C1

FIELD: medicine.

SUBSTANCE: reservatrol efficacy is studied in female Wistar rats with simulated osteoporosis by bilateral ovariectomy. For osteoporosis correction, reservatrol is administered in animal intraperitoneally for eight weeks after ovariectomy daily once a day in single dose 2 mg/kg. Osteoprotective action of reservatrol is estimated by a bone tissue microcirculation level and width of trabeculas of bone.

EFFECT: improved blood circulation and microarchitectonics of bone tissue in hypoestrogenic condition.

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RU 2 437 161 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gudyrev Oleg Sergeevich

Fajtel'Son Aleksandr Vladimirovich

Koklina Natal'Ja Jur'Evna

Artjushkova Elena Borisovna

Pokrovskaja Tat'Jana Grigor'Evna

Korokin Mikhail Viktorovich

Korokina Lilija Viktorovna

Belous Aleksandr Sergeevich

Kochkarov Vladimir Iskhakovich

Danilenko Ljudmila Mikhajlovna

Gladchenko Mikhail Petrovich

Gureev Vladimir Vladimirovich

Kolesnik Inga Mikhajlovna

Stabrovskaja Nadezhda Vladimirovna

Ragulina Vera Alekseevna

Ivanov Aleksandr Viktorovich

Jakushev Vladimir Ivanovich

Dates

2011-12-20—Published

2010-04-12—Filed