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IPC

C12N15/70(2006-01-01)

C12N15/40(2006-01-01)

C12N1/21(2006-01-01)

(21) (22)

Application

2008115680/13, 2008-04-21

(24)

Start date

2008-04-21

(22)

Actual filing date

2008-04-21

(45)

Published

2010-01-10

(72)

Inventor

Levanov Lev NikolaevichTikunova Nina ViktorovnaMatveev Leonid EhduardovichGoncharova Elena PavlovnaJun Tat'Jana EhverestovnaRyzhikov Aleksandr BorisovichMatveeva Vera AleksandrovnaRikhter Vladimir Aleksandrovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Khimicheskoj Biologii I Fundamental'Noj Meditsiny Sibirskogo Otdelenija Ran So Ran)Federal'Noe Gosudarstvennoe Uchrezhdenie Nauki Gosudarstvennyj Nauchnyj Tsentr Virusologii I Biotekhnologii Federal'Noj Sluzhby Po Nadzoru V Sfere Prav Potrebitelej I Blagopoluchija Cheloveka Gnts Vb Rospotrebnadzora)

RECOMBINANT PLASMID DNA pSC13D6 CONTAINING GENE OF ONE-CHAINED ANTIBODY TO TICK-BORNE ENCEPHALITIS VIRUS, AND STRAIN OF BACTERIA Escherichia coli BL21 (DE3)/pSC13D6-PRODUCER OF ONE-CHAINED ANTIBODIES TO TICK-BORNE ENCEPHALITIS VIRUS, EXPRESSING VIRUS NEUTRALISING PROPERTIES Russian patent published in 2010 - IPC C12N15/70 C12N15/40 C12N1/21

Abstract RU 2378378 C1

FIELD: medicine.

SUBSTANCE: there is designed recombinant plasmid DNA pSC13D6 containing a gene of one-chained antibody to tick-borne encephalitis virus sc13D6. Plasmid consists of 3782 basepairs and contains: a plasmid vector pGEMl, phage T7 promotor and unique restriction sites. There is also discovered strain of bacteria Escherichia coli BL21 (DE3)/pSC13D6 - a producer of a virus neutralising one-chained antibody sc13D6 to tick-borne encephalitis virus.

EFFECT: invention allows producing one-chained antibodies sc13D6 to tick-borne encephalitis virus able to inhibit it effectively.

2 cl, 5 dwg, 5 ex

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RU 2 378 378 C1

Authors

Levanov Lev Nikolaevich

Tikunova Nina Viktorovna

Matveev Leonid Ehduardovich

Goncharova Elena Pavlovna

Jun Tat'Jana Ehverestovna

Ryzhikov Aleksandr Borisovich

Matveeva Vera Aleksandrovna

Rikhter Vladimir Aleksandrovich

Dates

2010-01-10—Published

2008-04-21—Filed