METHOD FOR IN VITRO SLOW DOWN OF INITIAL STAGES OF DIFFERENTIATING EMBRYONIC STEM CELLS OF MAMMALS EXCEPT PRIMATES Russian patent published in 2010 - IPC C12N5/00 

Abstract RU 2396341 C1

FIELD: chemistry; biochemistry.

SUBSTANCE: invention relates to biotechnology and cell biology. It has been established that sensitivity of mouse embryonic stem cells to clinostatting increases depending on cell development stages: from embryonic stem cell colonies to embryoid bodies. It has been shown that embryoid body clinostatting leads to slow down of the beginning of cardiomyocyte differentiation and significant reduction of the amount of cardiomyocytes cut. The invention can also be used in space medicine.

EFFECT: delay of neuronal differentiation on later differentiation stages.

2 cl, 8 dwg, 1 tbl, 1 ex

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RU 2 396 341 C1

Authors

Konstantinova Natal'Ja Aleksandrovna

Buravkova Ljudmila Borisovna

Manuilova Ekaterina Semenovna

Grivennikov Igor' Anatol'Evich

Grigor'Ev Anatolij Ivanovich

Dates

2010-08-10Published

2009-06-29Filed