9-SUBSTITUTED DERIVATIVE OF 8-OXOADENINE AND MEDICINAL AGENT Russian patent published in 2010 - IPC C07D473/18 A61K31/522 A61K31/5377 A61P31/12 A61P35/00 A61P37/02 A61K31/08 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel compounds - 9-substituted derivatives of 8-oxoadenine of general formula (I) and their pharmaceutically acceptable salts having interferon-inducing effect on viruses. In general formula (I): , ring A is phenyl; n equals 0; Z¹ is a C₁-C₄alkylene group which is not substituted or substituted with a hydroxyl group; X² is an oxygen atom, a sulphur atom, SO₂, NR⁵, SO₂NR⁵, NR⁵SO₂ or NHCONH (in which R⁵ is a hydrogen atom, a substituted or unsubstituted C₁-C₆alkyl group, where the substitutes are selected from a hydroxyl group, C₁-C₆-alkoxy group, amino, C₁-C₆-alkylamino, di- C₁-C₆-alkylamino, 5-6-member saturated cycloamine group containing 1-2 nitrogen atoms, possibly containing an extra oxygen atom and possibly substituted with an oxo-group, and a tetrazolyl group); Y¹, Y² and Y³ each independently denotes a single bond or a C₁-C₄-alkylene group; X is an oxygen atom; R² is a hydrogen atom, a C₁-C₄-alkyl group optionally substituted with an amino group, a C₁-C₆-alkylamino group or a di- C₁-C₆-alkylamino group and R¹ is a hydrogen atom.

EFFECT: obtaining novel compounds which can be used as an antiviral or antiallergic agent.

14 cl, 32 tbl, 51 ex