METHOD OF DIAGNOSING NICKEL NEPHROPATHY IN EXPERIMENTAL ANIMALS IN CASE OF CHRONICPOISONING Russian patent published in 2010 - IPC G01N33/48 A61B5/145 

FIELD: medicine.

SUBSTANCE: in animals in erythrocytes and renal tissue concentration of malone dialdehyde (MDA) and activity of Na+, K+-ATP-ase of renal tissue are determined simultaneously. If MDA values are 4.88±0.03 nmole/ml of erythrocital mass and higher, and in cells of cortical and medullary renal tissue respectively 2.18±0.03 and 3.57±0.06 nmol/ml of protein and higher and values of activity of Na+, K+-ATP-ase of cortical and medullary renal tissue 2.21±0.08 and 5.39±0.13 mcmol "Рн" /mg protein/hour and lower respectively, nephropathy is diagnosed. In diagnostics of nickel nephropathy by said method taken into account are disorders of renal water- and electrolyte-excretory function, as well as pathogenic mechanisms of said disorders.

EFFECT: possibility to apply method in analysis of pathogenic mechanisms of toxic action of heavy and non-ferrous metals, in particular nickel, on functional state of kidneys.

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