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2 408 571

(13)

(51)

IPC

C07C49/323(2006-01-01)

C07C45/45(2006-01-01)

(21) (22)

Application

2008152917/04, 2008-12-31

(24)

Start date

2008-12-31

(22)

Actual filing date

2008-12-31

(45)

Published

2011-01-10

(72)

Inventor

Dzhemilev Usein MemetovichKhusnutdinov Ravil IsmagilovichShchadneva Nina AlekseevnaMukhametshina Lilija Fagimovna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Neftekhimii I Kataliza Ran

METHOD OF PRODUCING 1-ACETYLADAMANTANE Russian patent published in 2011 - IPC C07C49/323 C07C45/45

Abstract RU 2408571 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing 1-acetyladamantane, which is used in synthesis of several substituted adamantanes and is starting material in preparation of medicinal agents having antibacterial and antiviral activity, the most common of which is Remantadin. Also, alkyladamantyl ketones (including 1-acetyladamantane) are recommended for use in veterinary medicine for treating Newcastle disease. The method involves reacting 1-chloroadamantane with ethyledene diacetate (EDA) in a medium of carbon tetrachloride in the presence of a nickel-containing catalyst (Ni(acac)₂, NiBr₂(PPh₃)₂, NiCl₂(PPh₃)₂ or NiCl₂(PBu₃)₂), activated with acetonitrile, at temperature 160-180°C for 5-7 hours, in molar ratio [1-chloradamantane] : [EDA] : [CCl₄] : [catalyst] : [CH₃CN]=100:100-200:200:3-5:10-15.

EFFECT: invention enables production of the end product using a simple method with output of 85-90%.

1 tbl, 1 ex

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RU 2 408 571 C2

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Shchadneva Nina Alekseevna

Mukhametshina Lilija Fagimovna

Dates

2011-01-10—Published

2008-12-31—Filed