METHOD TO FORECAST VERSION OF DEVELOPMENT OF CERVICAL INTRAEPITHELIAL NEOPLASIA OF UTERINE NECK OF I DEGREE (CIN I) Russian patent published in 2011 - IPC A61B10/02 G01N1/28 

FIELD: medicine.

SUBSTANCE: invention refers to the field of medicine, namely to obstetrics and gynaecology. To forecast version of development of cervical intraepithelial neoplasia of I degree (CIN I), expression of P16ink4α is determined. Additionally colposcopical images are assessed using index Reid, of Coppleson system, extent of coilocytosis prevalence is identified in biopsy material. Examined parametres are assessed using prognostic coefficients (PC). In case of colposcopical Reid index of 0-2 points, value of PC=-3, 3 points - PC=+2, 4 points - PC=+1. In case of registration of meaningful colposcopical images by Coppleson PC=+2, non-meaningful - PC=-2. In case of availability of prevalent coilocytosis PC=+4, in case of its absence PC=-1. In case level of cytoplasmic marker P16ink4α 1-10% PC=-4, in case level of P16ink4a 11-50% - PC-2, in case level of P16ink4α is 51% and more - PC=+5. Prognostic coefficients are summed, and if sum of prognostic coefficients reaches final value with sign "+" - decision is made on risk of unfavourable version of CIN I development, and surgical treatment of uterine neck is recommended, if threshold with sign "-" is achieved - on favourable version of CIN I development, and conservative treatment of patient is recommended.

EFFECT: method makes it possible to determine option of CIN I development for justified medical tactics in treatment of this disease.

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