FIELD: medicine.
SUBSTANCE: gene and point mutations therein are identified by hybridisation of DNA biotin marked within polymerase chain reaction, with microchip immobilised specific oligonucleotides. Biotin in microchip DNA duplexes is detected by a streptavidin-peroxidase conjugate that is followed with colorimetric peroxidase detection.
EFFECT: invention can be used in clinical microbiological laboratories and epidemiological surveillance services for assessing resistance of an agent of infection of Enterobacteriaceae family to antibiotics of penicillin and cephalosporin group by observing the mutations in coding genes.
5 dwg, 2 tbl, 4 ex
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Number |
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2007 |
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2013 |
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2020 |
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2004 |
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2016 |
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