FIELD: medicine.
SUBSTANCE: genes and mutations therein are indentified on a DNA-microchip by hybridisation analysis, wherein a marked DNA is hybridised with immobilised oligonucleotides to assess thereafter mark activity in DNA duplexes on a carrier surface. The invention can be used in clinical microbiological laboratories and epidemiological surveillance services for assessing resistance of an agent of infection of Enterobacteriaceae family to antibiotics of penicillin and cephalosporin group by observing the mutations in coding genes.
EFFECT: new compounds show effective biological properties.
4 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR IDENTIFYING EXTENDED SPECTRUM CLASS A BETA-LACTAMASE GENES | 2009 |
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| METHOD FOR IDENTIFYING MUTATIONS IN THE GENE OF PENICILLIN-BINDING PROTEIN 2 PENA NEISSERIA GONORRHOEAE, LEADING TO RESISTANCE TO BETA-LACTAM ANTIBIOTICS, ON BIOLOGICAL MICROCHIPS | 2020 |
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| SETS OF OLIGONUCLEOTIDE PRIMERS AND PROBES, BIOLOGICAL MICROCHIP AND TEST SYSTEM FOR IDENTIFYING AND TYPING INFLUENZA A AND B VIRUS WITH USING THEM | 2013 |
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| METHOD FOR ANALYSIS OF GENETIC POLYMORPHYSM, DEFINING PREDISPOSITION TO TUMOR DISEASES AND INDIVIDUAL SENSITIVITY TO PHARMACEUTICAL AGENTS BY USING OLYGONUCLEOTIDE BIOLOGICAL MICROARRAY (BIOARRAY) | 2005 |
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| METHOD FOR DETERMINING GENETIC DETERMINANTS OF RESISTANCE OF THE PATHOGEN OF TUBERCULOSIS TO BEDAQUILINE AND LINEZOLID | 2017 |
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| METHOD FOR ANALYSIS OF SOMATIC MUTATIONS IN PI3K GENE USING LNA-BLOCKING MULTIPLEX PCR AND SUBSEQUENT HYBRIDISATION WITH OLIGONUCLEOTIDE BIOLOGICAL MICROCHIP (BIOCHIP) | 2013 |
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| METHOD OF ANALYSIS OF SOMATIC MUTATIONS IN THE BCR/ABL CHIMERIC GENE USING RT-PCR AND SUBSEQUENT HYBRIDIZATION WITH OLIGONUCLEOTIDE BIOLOGICAL MICROCHIP (BIOCHIP) | 2015 |
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