METHOD FOR PRODUCING LOW-MOLECULAR CHITOSAN Russian patent published in 2011 - IPC A61K31/722 A23L1/56 C08B37/08 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to producing chitin and its derivatives, namely to methods for producing low-molecular chitosan. Low-molecular chitosan is produced by dissolving high-molecular chitosan in 1% aqua acetic acid. It is added with hydrogen peroxide in amount 0.5-1.5 wt % to total solution in the presence of catalytic amounts of manganese oxide (IV). The solution is kept at temperature 18-50°C for 30 min. Upon completing reaction time, it is added with an aqueous solution of ammonia, with reducing pH of the reaction mixture to 6.9-7.0. After setting of sediment, acetone is added, and the solution is kept for 2 hours. The sediment is filtered, washed with distilled water and acetone, dried.

EFFECT: use of the method provides producing the end-product with a smaller degree of polydispersity and composition heterogeneity.

2 dwg, 2 tbl, 5 ex