FIELD: chemistry.
SUBSTANCE: method involves dispersing in water of high molecular weight chitosan with a molecular weight of 190-250 kDa with vigorous stirring, subsequent treatment in a 9.00-17.00% aqueous solution of sulfuric acid at 100-120°C for 20-55 minutes for homogeneous hydrolysis. The hydrolysis product is then precipitated from the sulfuric acid solution by introducing a 10% sodium hydroxide solution into the hot solution at a volume ratio of sodium hydroxide to sulfuric acid of 1:0.667. The product obtained is washed and dried at room temperature.
EFFECT: invention makes it possible to obtain low molecular weight chitosan with a molecular weight of 5-20 kDa with a high degree of crystallinity, thermal stability, antimicrobial activity and biological compatibility.
1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BIOSTIMULANT OF GROWTH OF AGRICULTURAL PLANTS FROM CHITIN OF CRUSTACEANS AND METHOD OF PRODUCTION OF BIOSTIMULANT OF GROWTH OF AGRICULTURAL PLANTS FROM CHITIN OF CRUSTACEANS | 2012 |
|
RU2504953C2 |
| METHOD OF PRODUCING CHITOSAN GLUTAMATE NANOPARTICLES | 2013 |
|
RU2562723C2 |
| METHOD FOR PRODUCING LOW-MOLECULAR CHITOSAN | 2010 |
|
RU2417088C1 |
| METHOD OF PRODUCING CHITOSAN NANOPARTICLES | 2019 |
|
RU2727360C1 |
| METHOD OF PRODUCING NANOPARTICLES OF LOW-MOLECULAR CHITOSAN | 2010 |
|
RU2428432C1 |
| METHOD OF PRODUCING CHITOSAN SUCCINATE NANOPARTICLES | 2013 |
|
RU2562721C2 |
| METHOD OF PRODUCING CHITOSAN ASPARTATE NANOPARTICLES | 2019 |
|
RU2713138C1 |
| METHOD OF BIOACTIVE CHITOSAN-BASED COATING APPLICATION ON POLYMER POROUS STRUCTURES | 2015 |
|
RU2600652C1 |
| SOLUTION FOR PREPARING CHITOSAN MATERIAL, METHOD FOR PREPARING HAEMOSTATIC MATERIAL OF THIS SOLUTION (VERSIONS) AND MEDICAL DEVICE WITH USING CHITOSAN FIBRES | 2011 |
|
RU2487701C2 |
| CHITOSAN PRODUCT, METHOD FOR ITS PREPARING (VARIANTS) | 2005 |
|
RU2313538C2 |
