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2 434 848

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(51)

IPC

C07C255/45(2006-01-01)

C07C255/47(2006-01-01)

C07C253/00(2006-01-01)

(21) (22)

Application

2009144372/04, 2009-11-30

(24)

Start date

2009-11-30

(22)

Actual filing date

2009-11-30

(45)

Published

2011-11-27

(72)

Inventor

Dzhemilev Usein MemetovichKhusnutdinov Ravil IsmagilovichShchadneva Nina AlekseevnaMajakova Julija Jur'Evna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Neftekhimii I Kataliza Ran

METHOD OF PRODUCING 1-CHLORO-3-CYANOADAMANTANE Russian patent published in 2011 - IPC C07C255/45 C07C255/47 C07C253/00

Abstract RU 2434848 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 1-chloro-3-cyanoadamantane of formula (I), which can be used in synthesis of biologically active 1,3-disubstituted adamantane derivatives and also as an intermediate in synthesis of medicinal agents. The method involves reaction of adamantyl-1-carboxylic acid or acyl chloride thereof with acetonitrile or tetrachloromethane in the presence of a vanadium catalyst VO(acac)₂ in molar ratio [VO(acac)₂]:[Ad-R]:[CH₃CN]:[CCl₄] = 1:(100-1000):(100-1000):(100-2000) (R = COOH, COCl), temperature 125-150°C for 1-3 hours.

EFFECT: method enables to obtain 1-chloro-3-cyanoadamantane with high output and 100% conversion of adamantyl-1-carboxylic acid or acyl chloride thereof.

1 tbl, 2 ex

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RU 2 434 848 C2

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Shchadneva Nina Alekseevna

Majakova Julija Jur'Evna

Dates

2011-11-27—Published

2009-11-30—Filed