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IPC

A61K38/18(2006-01-01)

A61P19/10(2006-01-01)

(21) (22)

Application

2013143186/15, 2013-09-23

(24)

Start date

2013-09-23

(22)

Actual filing date

2013-09-23

(45)

Published

2015-02-10

(72)

Inventor

Gudyrev Oleg SergeevichRemizov Pavel PavlovichSobolev Mikhail SergeevichFajtel'Son Aleksandr VladimirovichPokrovskij Mikhail VladimirovichRadzhkumar Densing Samuehl RadzhPokrovskaja Tat'Jana Grigor'EvnaKorokin Mikhail ViktorovichKochkarov Vladimir IskhakovichArustamova Anna AleksandrovnaNarykov Roman AleksandrovichAvtina Tat'Jana Valer'EvnaZatolokina Marija Alekseevna

(73)

Holder

Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"

METHOD FOR RECOMBINANT ERYTHROIETIN CORRECTION OF BONE TISSUE MICROCIRCULATION ACCOMPANYING SIMULATED OSTEOPOROSIS AND ASSOCIATED FRACTURES Russian patent published in 2015 - IPC A61K38/18 A61P19/10

Abstract RU 2541181 C1

FIELD: medicine.

SUBSTANCE: osteoporosis is simulated by a bilateral ovariectomy and osteoporosis-related femoral factures in Wistar rats; the pathological conditions are corrected by a pharmacological correction with recombinant erythropoietin in a sub-erythrostimulating dose of 50 international units/kg administered once a week as a single subcutaneous injection for eight weeks, and for twelve weeks in case of the fractures associated with simulated osteoporosis.

EFFECT: invention enables preventing the negative changes in the bone tissue microcirculation accompanying osteoporosis and in a callus in the osteoporosis-related fractures.

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RU 2 541 181 C1

Authors

Gudyrev Oleg Sergeevich

Remizov Pavel Pavlovich

Sobolev Mikhail Sergeevich

Fajtel'Son Aleksandr Vladimirovich

Pokrovskij Mikhail Vladimirovich

Radzhkumar Densing Samuehl Radzh

Pokrovskaja Tat'Jana Grigor'Evna

Korokin Mikhail Viktorovich

Kochkarov Vladimir Iskhakovich

Arustamova Anna Aleksandrovna

Narykov Roman Aleksandrovich

Avtina Tat'Jana Valer'Evna

Zatolokina Marija Alekseevna

Dates

2015-02-10—Published

2013-09-23—Filed