METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF ATORVASTATIN AND RESVERATROL IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY Russian patent published in 2011 - IPC G09B23/28 A61K31/401 A61K31/05 A61P9/00 A61P9/08 

Abstract RU 2438188 C1

FIELD: medicine.

SUBSTANCE: endothelial dysfunction is ensured by intragastric introduction to a laboratory animal of the NO-synthase inhibitor - N-nitro-L-arginine of methyl ester (L-NAME) 25 mg/kg daily for 7 days. The endothelial dysfunction correction is ensured by intragastric introduction of atorvastatin 2.2 mg/kg and intragastric introduction of resveratrol 2 mg/kg once a day.

EFFECT: effective action of the combination of two specified preparations on vascular endothelium function.

1 ex, 2 tbl

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RU 2 438 188 C1

Authors

Dolzhenkova Tat'Jana Vladimirovna

Jakushev Vladimir Ivanovich

Pokrovskaja Tat'Jana Grigor'Evna

Beskhmel'Nitsyna Evgenija Aleksandrovna

Pokrovskij Mikhail Vladimirovich

Belous Aleksandr Sergeevich

Artjushkova Elena Borisovna

Gudyrev Oleg Sergeevich

Korokin Mikhail Viktorovich

Kljavs Jurij Petrovich

Kuprijanova Jana Sergeevna

Dates

2011-12-27Published

2010-04-12Filed