HETEROCYCLIC COMPOUNDS HAVING 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITING ACTIVITY Russian patent published in 2012 - IPC C07D231/20 C07D231/18 C07D401/06 C07D401/12 C07D403/06 C07D403/12 C07D403/14 C07D409/12 C07D413/12 C07D419/06 C07D413/06 A61K31/415 A61K31/4152 A61K31/4155 A61K31/4178 A61K31/4439 A61K31/454 A61K31/4709 A61P3/04 A61P3/06 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula

,

and pharmaceutically acceptable salts and solvates thereof, in which R¹ is an optionally substituted alkyl or similar, R² is a group of formula: -Y-R⁵, where Y is -O- or S; R⁵ is a substituted alkyl (the substitute is an optionally substituted cycloalkyl or similar), a branched alkyl or similar; R⁴ is hydrogen or C_1-10 alkyl; R³ is a group of formula: -C(=O)-Z-R⁶, where Z is -NR⁷- or -NR⁷-W-; R⁶ is an optionally substituted cycloalkyl or similar; R⁷ is hydrogen or C_1-10 alkyl, W is C_1-10 alkylene; X is =N- provided that a compound in which R² is 2-(4-morpholino)ethoxy, 2-, 3- or 4-pyridylmethoxy, 1-methylpiperidinyl-2-methoxy, benzyloxy or 4-substituted benzyloxy is excluded; and R³ is N-(1-adamantyl)carbamoyl, N-(2-adamantyl)carbamoyl and N-(3-noradamantyl)carbamoyl. Said compound is an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. The invention also relates to a pharmaceutical composition containing said compound as an active ingredient.

EFFECT: improved properties of the compound.

23 cl, 72 ex