METHOD FOR EVALUATION OF CEPHALOSPORIN ANTIBIOTICS IN BIOLOGICAL MEDIA Russian patent published in 2012 - IPC G01N33/48 G01N33/15 

FIELD: medicine.

SUBSTANCE: method for evaluation of cephalosporin antibiotics both in oral fluid and whole blood that involves sampling of oral fluid and whole blood containing an antibiotic that is followed by sample preparation to remove solid elements, and to settle and remove proteins, measurement of the intrinsic absorption UV-spectra of the antibiotic in the specific range as shown by a calibration curve constructed by a reference medium with the calibration curve constructed to comply with the measured optical densities from the antibiotic concentration in a reference solution; using whole blood as a biological medium requires blood corpuscles to be removed for the purpose of sample preparation.

EFFECT: method provides cutting time for evaluation of cephalosporin antibiotics with a reduced detection level, higher detection accuracy, lower uncertainty of the result.

2 cl, 6 dwg, 1 tbl, 4 ex