BENZIMIDAZOLYLPYRIDYL ESTER COMPOUNDS Russian patent published in 2012 - IPC A61K9/107 A61K31/4184 A61K31/4439 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to pharmacology and concerns liquid compounds intended for RAF kinase inhibition, angiogenesis inhibition and/or cancer treatment, as well as to methods for preparing liquid compounds. The compounds contain {1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)pyridine-4-yloxy]-1H-benzimidazol-2-yl}(4-trifluoromethylphenyl)amine (the compound of formula I), its pharmaceutically acceptable salt or a mixture of any of two or more of said compound or its salts, a hydrophilic solvent containing ethanol, polyethylene glycol or their mixture, a lipophilic solvent containing fatty acid and an emulsifier. A method for making the liquid compound involves mixing the components specified above.

EFFECT: group of inventions provides higher bioavailability of the compound of formula I.

39 cl, 7 tbl, 6 ex