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2 448 953

(13)

(51)

IPC

C07C233/06(2006-01-01)

C07C231/06(2006-01-01)

(21) (22)

Application

2010131801/04, 2010-07-28

(24)

Start date

2010-07-28

(22)

Actual filing date

2010-07-28

(45)

Published

2012-04-27

(72)

Inventor

Dzhemilev Usein MemetovichKhusnutdinov Ravil IsmagilovichShchadneva Nina AlekseevnaKhisamova Lilija Fagimovna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Neftekhimii I Kataliza Ran

METHOD OF PRODUCING N-(1-ADAMANTYL)ACETAMIDE Russian patent published in 2012 - IPC C07C233/06 C07C231/06

Abstract RU 2448953 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a novel method of producing N-(1-adamantyl)acetamide, which is a close precursor of biologically active amines, having antimicrobial and antiviral activity, involving reaction of adamantanol-1 with acetonitrile in an aqueous medium, characterised by that the reaction is carried out in the presence of manganese-containing catalysts Mn(OAc)₂, Mn(acac)₃ and Mn(CO)₁₀, activated with hydrobromic acid, in molar ratio [adamantanol-1]:[CH₃CN]:[H₂O]:[catalyst]:[HBr] = 100:800:100:1-3:1-3.

EFFECT: obtaining a single reaction product (N-(1-adamantyl)acetamide) and high conversion (95%) of adamantanol-1.

2 cl, 8 ex, 1 tbl

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RU 2 448 953 C2

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Shchadneva Nina Alekseevna

Khisamova Lilija Fagimovna

Dates

2012-04-27—Published

2010-07-28—Filed