FIELD: medicine.
SUBSTANCE: group of inventions refers to methods for producing an antibody preparation with a lower level of host cell proteins (HCP) from a mixture containing an antibody and at least one HCP involving the stage of ion-exchange separation wherein the mixture is exposed to a first ion-exchange material so that to produce the antibody preparation with the lower level of HCP.
EFFECT: group of inventions enables fast and qualitative purification of the antibody preparation.
64 cl, 6 dwg, 18 tbl, 4 ex
| Title |
Year |
Author |
Number |
| SEPARATION AND PURIFICATION OF ANTIBODIES WITH APPLICATION OF PROTEIN A-BASED AFFINITY CHROMATOGRAPHY |
2009 |
- Khikman Robert K.
- Khuan Tsin
- Uid Cheril L.
- Ehnnis Skott T.
- Perilli-Palmer Barbara
- Van' Min'
|
RU2520838C2 |
| PURIFICATION OF ANTIBODIES WITH HELP OF SIMULATED MOVING BED CHROMATOGRAPHY |
2011 |
- Lej Saju-Man Kelvin
- Dong Dajan
- Lu Stefen
|
RU2608499C2 |
| VIRUS INACTIVATION IN ANTIBODY PURIFICATION |
2009 |
- Khikman Robert K.
- Korreja Ivan R.
|
RU2551237C2 |
| ISOLATION AND PURIFICATION OF ANTI-IL-13 ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY |
2010 |
|
RU2603055C2 |
| ANTIBODY PURIFICATION METHODS |
2017 |
- Dumetz, Andre C.
- Goklen, Kent E.
- Levy, Nicholas E.
- Molek, Jessica Rachel
- Thomson, Andrew S.
- Yancey, Kenneth G.
|
RU2759909C2 |
| IMPROVING IMMUNOGLOBULIN AFFINITY CHROMATOGRAPHY BY THE APPLICATION OF PRE-CAPTURE FLOCULATION |
2020 |
- Keszey, Zsuzsanna
- Suto, Zoltan
|
RU2794431C1 |
| IMPROVED METHODS OF PURIFYING VECTORS BASED ON RECOMBINANT AAV |
2010 |
- Sheldon Polin Maklin Kuigli
- Ganon Piter S.
- Nikols Dzhina
- Torn Barbara A.
|
RU2588387C2 |
| METHOD OF OBTAINING PREPARATION OF ANTIBODY AGAINST IL-18 OR ITS ANTIGEN-BINDING PART (VERSIONS) |
2009 |
- Khikman Robert K.
- Khuan Tsin
- Zherve Dzhoanna
|
RU2514657C2 |
| COMPLETELY SCALABLE METHOD FOR PRODUCING rAAV BASED ON COLUMNS |
2017 |
- Qu, Guang
- Oh, Younghoon
- Lu, Lin
- Wright, John Fraser
|
RU2754467C2 |
| METHOD OF AFFINITY CHROMATOGRAPHY TO OBTAIN PURIFIED PROTEIN |
2012 |
|
RU2609633C2 |
