CONDENSED BICYCLIC COMPOUND Russian patent published in 2012 - IPC C07D265/16 C07D311/58 C07D413/04 A61K31/352 A61K31/536 A61P9/00 

FIELD: medicine.

SUBSTANCE: invention relates to condensed bicyclic compounds, having affinity with mineralocorticoid receptor (VR) of formula [I] and formula [ii], as well as to pharmaceutical compositions on their basis. In general formula [I[ and [ii] ring A represents benzene ring, which has substituent R¹, condensed with adjacent 6-membered heterocyclic ring, and said benzene ring additionally optionally is substituted with one or two substituent(s), selected from halogen atom and C_1-8-alkyl group, R¹ represents C_1-8-alkylsulfonyl amino group or C_1-8-alkyl aminosulfonyl group, R² and R³ (a) are similar or different and represent group, selected from hydrogen atom, C_1-8-alkyl group, and from 6- to 10-membered monocyclic or bicyclic aryl group (said aryl group is optionally substituted with halogen atom), (b) are combined with each other with formation of oxogroup or (c) are combined with each other on their ends together with adjacent carbon atom with formation of C_3-10-cycloalkyl group, X represents the following group =N-, =C(R⁴)- or -CH(R⁴)-, R⁴ represents hydrogen atom, cyanogroup, halogen atom, C_1-6-alkyl group, C_2-6-alkenyl group, C_3-10-dicloalkyl group, C_1-7-alkanoyl group, carbamoyl group or C_3-8cycloalkenyl group, Ar represents from 6- to 10-membered monocyclic or bicyclic aryl group, optionally containing one or several heteroatom(s), selected from sulphur atom, oxygen atom and nitrogen atom (said aryl group is optionally substituted with similar or different, one or two substituent(s), selected from halogen atom, cyanogroup, C_1-8-alkyl group, trihalogen- C_1-8-alkyl group and C_1-8alkoxygroup), and dotted line represents presence or absence of double bond, X^a represents the following group =N- or =C(CN)-, R^Z represents hydrogen atom or halogen atom, R²⁵ and R³⁵ represent alkyl group, and Ar³ represents phenyl group, optionally substituted with one or two group(s), which is(are) selected from halogen atom and trihalogenalkyl group.

EFFECT: compounds can be applied as antihypertensive medication.

15 cl, 18 tbl, 8 dwg, 71 ex