METHOD FOR DETECTING NEUROSYPHILIS IN PATIENTS INFECTED BY TREPONEMA PALLIDUM Russian patent published in 2013 - IPC G01N33/00 

FIELD: medicine.

SUBSTANCE: venous blood is sampled; test samples are prepared for serologic examination. It is followed by microprecipitation test (MT), complement fixation (CF) with Pangborn's (P) and treponemal (T) antigens, passive hemagglutination test (PHT) in qualitative and quantitative versions and enzyme-linked immunosorbent assay (ELISA). The patient is clinically examined. The serologic examination results, historical data and nervous system information used as relevant values are recorded and divided on four groups. Each of the values detected in the patient are scored by a degree of effect on the examination result. Within each group, the points are summed up, and diagnostic coefficients are prepared for each of four groups DC₁, DC₂, DC₃, DC₄. The coefficients are compared to the reference values. A criterion for the presence of neurosyphilis is the relation of the values of four patient's diagnostic coefficients to the reference values: DC₁≥4, DC₂≥8, DC₃≥35, DC₄≥-4. The absence of neurosyphilis in the patient is shown by the values of a set of the diagnostic coefficients less than the related reference values.

EFFECT: method enables objective assessment of the patient's state without sampling cerebrospinal fluid by lumbar puncture, and arriving at diagnosis on the basis of the derived findings.

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