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2 478 638

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(51)

IPC

C07D487/08(2006-01-01)

A61K31/551(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2011154533/04, 2011-12-29

(24)

Start date

2011-12-29

(22)

Actual filing date

2011-12-29

(45)

Published

2013-04-10

(72)

Inventor

Silajchev Pavel SergeevichMaslivets Andrej NikolaevichMakhmudov Ramiz Ragibovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"

DIMETHYL 2-ACYL-1-HYDROXY-3-METHYL-7-OXO-6-PHENYL-2,6-DIAZABICYCLO[3,2,1]OCT-3-ENE-5,8-DICARBOXYLATES AND METHOD FOR PREPARING THEM Russian patent published in 2013 - IPC C07D487/08 A61K31/551 A61P29/00

Abstract RU 2478638 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to dimethyl 4-acyl-1-hydroxy-3-methyl-7-oxo-6-phenyl-2,6-diazabicyclo[3.2.1]oct-3-ene-5,8-dicarboxylates of formula wherein Ar=Ph, C₆H₄Me-4, C₆H₄OMe-4, C₆H₄C1-4, C₆H₄Br-4; R=Me, Ph, as well as to a method for preparing them by setting a benzene solution of 1-aryl-4,5-bis(methoxycarbonyl)-1H-pyrrol-2,3-dions and 4-aminopent-3-en-2-one or 3-amino-1-phenylbut-2-en-1-one at room temperature.

EFFECT: compounds may be used as raw products for synthesis of new heterocyclic systems in pharmacology as potential drug preparations possessing analgesic activity.

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RU 2 478 638 C1

Authors

Silajchev Pavel Sergeevich

Maslivets Andrej Nikolaevich

Makhmudov Ramiz Ragibovich

Dates

2013-04-10—Published

2011-12-29—Filed