METHOD OF PRODUCING 3-AMINO-8-HYDROXY-1,6-DIOXO-2,7-DIAZASPIRO[4,4]NON-3-ENE-4-CARBONITRILES Russian patent published in 2013 - IPC C07D487/10 

Abstract RU 2495040 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing novel 3-amino-8-hydroxy-1,6-dioxo-2,7-diazaspiro[4.4]non-3-ene-4-carbonitriles of formula: , where R1=R2=CH3, R3=H; R1=R2=R3=CH3; R1=iPr, R2=R3=CH3, R1+R2=(CH2)4, R3=CH3; R1=Ph, R2=CH3, R3=H. The method involves dissolving the corresponding 4-oxoalkane-1,1,2,2-tetracarbonitrile in aqueous NaOH solution and holding for 1…2 at room temperature, after which the reaction mass is neutralised with 20…25% acetic acid to form the end product.

EFFECT: obtaining novel 3-amino-8-hydroxy-1,6-dioxo-2,7-diazaspiro[4,4]non-3-ene-4-carbonitriles.

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RU 2 495 040 C1

Authors

Fedoseev Sergej Vladimirovich

Ershov Oleg Vjacheslavovich

Lipin Konstantin Vladimirovich

Eremkin Aleksej Vladimirovich

Kajukov Jakov Sergeevich

Nasakin Oleg Evgen'Evich

Dates

2013-10-10Published

2012-05-03Filed