METHOD FOR PREPARING 6-IMINO-2,7-DIOXABICYCLO[3,2,1]OCTANE-4,4,5-TRICARBONITRILES Russian patent published in 2015 - IPC C07D491/08 

FIELD: chemistry.

SUBSTANCE: invention refers to methods for preparing functionally substituted condensed heterocyclic molecules, more specifically 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricar- bonitriles , wherein R¹=R²=Me, R³=Et (1); R¹=R²=Me, R³=Pr (2); R¹=R²=Me, R³=i-Pr (3); R¹=R²=Me, R³=Bu (4); R¹=R²=Me, R³=Ph (5); R¹=R²=Me, R³=4-Me-C₆H₄ (6); R¹=R²=Me, R³=3-F-C₆H₄ (7); R¹=R²=Me, R³=4-MeO-C₆H₄ (8); R¹=R²=Me, R³=4-NO₂-C₆H₄ (9); R¹=R²-Me, R³=2-Fu (10); R¹=R²=Me, R³=2-Thi (11); R¹=Et, R²=Me, R³=Ph (12); R¹=Et, R²=Me, R³=4-MeO-C₆H₄ (13); R¹=Et, R²=Me, R³=4-NO₂-C₆H₄ (14); R¹=Et, R²=Me, R³=2-Pyr (15); R¹=Et, R²=Me, R³=2-Fu (16); R¹=Me, R²=Pr, R³=Pr (17); R¹=Me, R²=Pr, R³=i-Pr (18); R¹=Me, R²=Pr, R³=Ph (19); R¹=Me, R²=Ph, R³=Et (20); R¹=Me, R²=Ph, R³=i-Pr (21); R¹=Me, R²=Ph, R³=Bu (22); R¹=Me, R²=Ph, R³=Ph (23); R¹=Me, R²=Ph, R³=3-F-C₆H₄ (24); R¹=Me, R²=Ph, R³=4-NO₂-C₆H₄ (25); R¹=Me, R²=Ph, R³=2-Fu (26); R¹+R²=(CH₂)₄, R³=Pr (27); R¹+R²=(CH₂)₄, R³=i-Pr (28); R¹+R²=(CH₂)₄, R³=Ph (29); R¹+R²=(CH₂)₄, R³=3-F-C₆H₄ (30); R¹+R²=(CH₂)₄, R³=4-MeO-C₆H₄ (31); R¹+R²=(CH₂)₄, R³=4-NO₂-C₆H₄ (32); R¹+R²=(CH₂)₄, R³=2-Pyr (33): R¹+R²=(CH₂)₄, R³=2-Fu (34); R¹+R²=(CH₂)₄, R³=2-Thi (35); R¹+R²=(CH₂).S R³-Ph (36); R¹+R²=(CH₂)₅, R³=3-F-C₆H₄ (37); R¹+R²=(CH₂)₅; R³=2-Pyr (38), which can be used as biologically active compounds. The method consists in the fact that respective 4-oxoalkane-1,1,2,2-tetracarbonitrile in aqueous acetic acid in the concentration of 50-85%; thereafter a reaction mass is added with respective 1,3,5-trisubstituted 2,4-diazapenta-1,4-diene in molar ratio 2:1; the reaction mass is agitated for 20-30 minute unit an end product is prepared.

EFFECT: fastening and simplifying the process.

38 ex