7-PIPERIDINOALKYL-3,4-DIHYDROQUINOLONE DERIVATIVES, HAVING ANTAGONISTIC ACTION ON MELANIN-CONCENTRATING HORMONE (MCH) RECEPTOR Russian patent published in 2013 - IPC C07D401/06 C07D401/14 A61K31/4709 A61P3/04 A61P15/10 A61P25/18 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to novel 7-piperidinoalkyl-3,4-dihydroquinolone derivatives and a pharmaceutically acceptable salt or hydrate thereof, where R is a hydrogen atom or a C_1-6-alkyl group; A¹, A² and A³, which can be identical or different, are each a hydrogen atom, a halogen atom; X is a C_1-6-alkylene group; Y is a bond or a C_1-6-alkylene group; Z is a bond or a C_1-6-alkylene group, where the C_1-6-alkylene group can be substituted with a phenyl group; W is a bond or an oxygen atom; and Cy is a phenyl group or a pyridyl group, where the phenyl or pyridyl group can have 1-3 substitutes which can be identical or different and are selected from a group consisting of a halogen atom, a cyano group, a C_1-6-alkyl group, C_1-6-alkoxy group, where the C_1-6-alkyl group or C_1-6-alkoxy group can be substituted with 1-3 halogen atoms, and a C_2-6-alkanoyl group. The invention also relates to a pharmaceutical composition and a preventive or therapeutic drug based on the compound of formula (I) .

EFFECT: obtaining novel 7-piperidinoalkyl-3,4-dihydroquinolone derivatives, having antagonistic action on MCH receptor.

6 cl, 4 tbl, 10 ex