FIELD: chemistry.
SUBSTANCE: invention relates to an agent for inhibiting the human poly(ADP-ribose)polymerase-1 enzyme, which is 6-acetyl-7;9-dihydroxy-8,9b-dimethyl-2-ethylid-2,11-ene-1,9b,2,3-tetrahydro-11-N-carboxyphenylmethylamino-1,3-dioxodibenzofuran of general formula (I): 
Said agent exhibits specific inhibiting action on the human poly(ADP-ribose)polymerase-1 (PARP-1) enzyme.
EFFECT: cheap method, wider range of specific inhibitors of said enzyme and enabling use in developing drugs in clinical medicine.
1 cl, 2 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MEDICATION FOR INHIBITING HUMAN ENZYME POLY(ADP-RIBOSE)POLYMERASE-1 | 2009 |
|
RU2411948C1 |
| AGENT FOR POLY(ADP-RIBOSO) POLYMERASE INHIBITION | 2012 |
|
RU2522915C2 |
| PREPARING QUATERNISED USNIC ACID DERIVATIVES AND THEIR BIOLOGICAL PROPERTIES | 2012 |
|
RU2477127C1 |
| AGENT FOR INHIBITING HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME | 2015 |
|
RU2605329C1 |
| INHIBITORS OF HUMAN POLY(ADP-RIBOSO)POLYMERASE-1 BASED ON URACYL DERIVATIVES | 2012 |
|
RU2527457C2 |
| 2-ACETYL-6-(2-(2-(4-BROMBENZYLIDENE)HYDRAZINYL)THIAZOL-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMETHYLDIOBENZO[B,D]FURAN-1(9BH)-OH, WITH INHIBITING ACTION ON HUMEN TYROSYL-DNA-PHOSPHODIESTERASE 1 | 2016 |
|
RU2627764C1 |
| HYDRAZINE THIAZOLE DERIVATIVES OF USNIC ACID WITH INHIBITORY ACTION TOWARDS HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME | 2015 |
|
RU2612256C1 |
| TRICYCLIC PARP INHIBITORS | 2004 |
|
RU2404183C2 |
| FURILIDENE FURANONE DERIVATIVES OF USNIC ACID AS NEW ANTITUBERCULOSIS AGENTS | 2013 |
|
RU2533707C1 |
| THERAPEUTIC COMBINATIONS CONTAINING INHIBITOR OF POLY(ADP-RIBOSE)POLYMERASE | 2005 |
|
RU2361592C2 |
