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IPC

A61M31/00(2006-01-01)

A61K31/616(2006-01-01)

A61P15/00(2006-01-01)

G09B23/28(2006-01-01)

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Application

2019137544, 2019-11-21

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Start date

2019-11-21

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Actual filing date

2019-11-21

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Published

2020-05-18

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Inventor

Gureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichLokteva Tatyana IvanovnaAntsiferova Oksana EvgenevnaYurakova Alesya ViktorovnaPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaZhilinkova Lyudmila AnatolevnaZatolokina Mariya AlekseevnaShchurovskaya Kristina VladimirovnaKolesnichenko Pavel DmitrievichPakhomov Sergej PetrovichSeverinova Olga VladimirovnaGolubev Ivan VladimirovichIvakhno Elena NikolaevnaPovetka Elena EvgenevnaGureeva Anastasiya VladimirovnaVajn Darya SergeevnaKudryavtsev Konstantin Viktorovich

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Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION IN AN ADMA-LIKE MODEL OF PREECLAMPSIA USING ACETYLSALICYLIC ACID Russian patent published in 2020 - IPC A61M31/00 A61K31/616 A61P15/00 G09B23/28

Abstract RU 2721290 C1

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely to experimental pharmacology. Method of endothelial dysfunction correction in the ADMA-like model of preeclampsia involves reproducing a pre-eclampsia model in the Wistar rats daily from 14th to 20th day of pregnancy by the intraperitoneal introduction of L-nitro-arginine-methyl ether in dose of 25 mg/kg, characterized by the fact that for the purpose of endothelial dysfunction correction, acetylsalicylic acid is administered orally in dose of 10 mg/kg once day from 14th to 20th day of pregnancy.

EFFECT: method provides marked correction of endothelial dysfunction with acetylsalicylic acid in conditions of a reproducible ADMA-like model of preeclampsia in pregnant rats.

1 cl, 1 tbl, 1 ex

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RU 2 721 290 C1

Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Lokteva Tatyana Ivanovna

Antsiferova Oksana Evgenevna

Yurakova Alesya Viktorovna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zatolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Kolesnichenko Pavel Dmitrievich

Pakhomov Sergej Petrovich

Severinova Olga Vladimirovna

Golubev Ivan Vladimirovich

Ivakhno Elena Nikolaevna

Povetka Elena Evgenevna

Gureeva Anastasiya Vladimirovna

Vajn Darya Sergeevna

Kudryavtsev Konstantin Viktorovich

Dates

2020-05-18—Published

2019-11-21—Filed