METHOD FOR ENDOTHELIOPROTECTION IN ADMA-SIMILAR GESTOSIS MODEL BY ARGINASE II INHIBITOR Russian patent published in 2017 - IPC G09B23/28 A61K31/195 A61P9/08 A61P15/06 

FIELD: pharmacology.

SUBSTANCE: method involves reproduction of gestosis in laboratory pregnant Wistar rats by daily intraperitoneal administration of the NO-synthase inhibitor L-NAME from day 14 to day 20 of pregnancy at a dose of 25 mg/kg/day. At that, correction of endothelial dysfunction is performed daily by intragastric administration of a selective inhibitor of arginase II-KUD975. Inhibitor administration is performed 30 minutes prior to the administration of L-NAME at a dose of 1 mg/kg of animal body weight.

EFFECT: pronounced correction of dysfunction under the conditions of specific mechanisms of the pathological process in pregnant women, with elimination of side effects typical for low- and nonselective arginase inhibitors.

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