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2 723 453

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IPC

A61M31/00(2006-01-01)

A61K31/353(2006-01-01)

A61K31/7048(2006-01-01)

A61P15/00(2006-01-01)

G09B23/28(2006-01-01)

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Application

2019138453, 2019-11-28

(24)

Start date

2019-11-28

(22)

Actual filing date

2019-11-28

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Published

2020-06-11

(72)

Inventor

Gureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichLokteva Tatyana IvanovnaAntsiferoa Oksana EvgenevnaYurakova Alesya ViktorovnaPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaZhilinkova Lyudmila AnatolevnaZatolokina Mariya AlekseevnaShchurovskaya Kristina VladimirovnaKolesnichenko Pavel DmitrievichPakhomov Sergej PetrovichSeverinova Olga VladimirovnaGolubev Ivan VladimirovichIvakhno Elena NikolaevnaPovetka Elena NikolaevnaGureeva Anastasiya VladimirovnaVajn Darya SergeevnaKudryavtsev Konstantin Viktorovich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION IN ADMA-LIKE MODEL OF PREECLAMPSIA USING DETRALEX Russian patent published in 2020 - IPC A61M31/00 A61K31/353 A61K31/7048 A61P15/00 G09B23/28 

Abstract RU 2723453 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental pharmacology. In order to correct endothelial dysfunction in ADMA-like model of preeclampsia, a pre-eclampsia model is reproduced in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg on 14th-20th day of pregnancy. Endothelial dysfunction is corrected by intragastrically introducing detralex 260 mg/kg once day on 14th-20th day of pregnancy.

EFFECT: invention promotes pronounced correction of endothelial dysfunction in conditions of reproduced ADMA-like model of preeclampsia in pregnant rats using detralex.

1 cl, 1 ex

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RU 2 723 453 C1

Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Lokteva Tatyana Ivanovna

Antsiferoa Oksana Evgenevna

Yurakova Alesya Viktorovna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zatolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Kolesnichenko Pavel Dmitrievich

Pakhomov Sergej Petrovich

Severinova Olga Vladimirovna

Golubev Ivan Vladimirovich

Ivakhno Elena Nikolaevna

Povetka Elena Nikolaevna

Gureeva Anastasiya Vladimirovna

Vajn Darya Sergeevna

Kudryavtsev Konstantin Viktorovich

Dates

2020-06-11—Published

2019-11-28—Filed

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