PHARMACEUTICAL COMPOSITION CONTAINING COATED MICROPARTICLES Russian patent published in 2014 - IPC A61K9/16 A61K38/00 A61K38/28 A61K47/30 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to pharmaceutics and consists in presenting a pharmaceutical composition applicable for the effective administration of low-molecular drug preparation and polymer compounds, such as peptides and proteins by a method, other than injection, and a method for preparing the given composition. The pharmaceutical composition for transmucosal administration contains (a) a positively or negatively charged drug preparation at pH of the prepared composition, (b) a pharmaceutically acceptable low particle having a size not less than 1 nm and no more than 50 mcm, and (c) a pharmaceutically acceptable coating polymer charged opposite in sign to the drug preparation at the above pH with a particle surface coated with a coating polymer, the drug substance fixed on the surface of the given particle by means of the coating polymer; and the complex is formed by a non-covalent interaction of the given low particle and the coating polymer, and a concurrent electrostatic interaction of the coating polymer and the drug preparation.

EFFECT: group of inventions provides higher stability, as well as control of the transmucosal absorption of the given drug preparation.

17 cl, 8 ex, 13 tbl, 10 dwg