FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 3α-hydroxy-10β-pinanone-4. The method involves oxidising 3α,4β-dihydroxy-10β-pinane in dimethylformamide without or in the presence of a MoCl5 or Mo(CO)6 catalyst for 1-2 hours while passing a current of chlorine dioxide gas. The reaction mixture is then extracted with diethyl ether or methyl-tert-butyl ether, washed and dried over anhydrous MgSO4. The end product is separated by chromatography on SiO2.
EFFECT: method enables to obtain 3α-hydroxy-10β-pinanone-4 with high output.
1 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING TERPENE α-CHLOROKETONES OR CHLOROHYDROXYKETONES | 2015 |
|
RU2569896C1 |
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|
RU2631871C1 |
| CARDIOPROTECTIVE AGENT AND ITS COMPOSITION | 1995 |
|
RU2166319C2 |
| TAXOIDS, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION BASED ON THESE COMPOUNDS | 1995 |
|
RU2153496C2 |
| COMPOUNDS, METHODS FOR THEIR PREPARING, USING, PHARMACEUTICAL COMPOSITION | 2002 |
|
RU2311418C2 |
| DERIVATIVES OF BENZAZEPINE AND BENZOTHIAZEPINE | 1989 |
|
RU2090562C1 |
| DERIVATIVES OF ARTEMISININ, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT | 1999 |
|
RU2236413C2 |
| TAXOIDS, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2139864C1 |
| PROCESS FOR PREPARING 7-HYDROXYTAXANES | 1995 |
|
RU2127730C1 |
| DERIVATIVES OF 3-H-1,2,3-TRIAZOLO-[4,5-D]-PYRIMIDINE, PHARMACEUTICAL COMPOSITION AND METHOD OF THEIR SYNTHESIS | 1996 |
|
RU2174518C2 |
