NANOSCALE ENZYME BIOCATALYST FOR in vivo DETOXIFICATION OF ORGANOPHOSPHOROUS COMPOUNDS Russian patent published in 2014 - IPC C12N11/02 C12N11/08 C12N9/16 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biotechnology. What is presented is an enzyme biocatalyst in the form of nanoscale particles for in vivo detoxification of organophosphorous compounds. The biocatalyst represents non-covalent polyelectrolyte complexes. The given complexes consist of a polyhistidine-containing polypeptide with the properties of organophosphosphorous hydrolase and polyethylene glycol-polyglutamic acid block copolymer in a charge relation of enzyme:block copolymer falling within the range of 2:1 to 1:5.

EFFECT: invention provides significant simplification of the biocatalyst technology, an increase of its catalytic efficiency, a dose decline, an immunotoxic suppression, as well as higher activity in hydrolysis reactions of pesticides and toxic materials.

4 cl, 6 ex