METHOD OF OBTAINING OF 2-(1-ADAMANTYL)-5R-TETRAZOLES, DEMONSTRATING ACTIVITY AGAINST TYPE A INFLUENZA VIRUS Russian patent published in 2014 - IPC C07D257/04 

FIELD: chemistry.

SUBSTANCE: described is an improved method of obtaining 2-(1-adamantyl)-5R-tetrazoles of general formula 1 , where: R=H, CH₃, C₂H₅, or phenyl, possibly substituted with NO₂ or F, consisting in the fact, that a reaction mixture, which consists of carbon acid nitrile (RCN), ammonium azide ( $$N{H}_4^{+}{N}_3^{-}$$ ) in a ratio of 1.2-1.8 mol of ammonium azide per 1 mol of nitrile in dimethylformamide, is heated at a temperature of 90-110°C by means of electromagnetic radiation with a frequency of 2450 MHz for not more than 2 hours, with the following processing of obtained 5R-tetrazole with 1-adamantanol in sulphuric acid with the concentration not less than 98 wt %.

EFFECT: method is safe, makes it possible to selectively obtain the target product with the high output due to reduction of a probability of a side process of thermal decomposition of 5R tetrazol and exclusion of a probability of ammonium azide sublimation, the target product is active against the virus of type A.

1 tbl, 7 ex