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2 458 705

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IPC

A61K47/02(2006-01-01)

A61K31/7064(2006-01-01)

A61P31/04(2006-01-01)

A61J3/00(2006-01-01)

B82B3/00(2006-01-01)

B82Y5/00(2011-01-01)

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Application

2011125003/15, 2011-06-17

(24)

Start date

2011-06-17

(22)

Actual filing date

2011-06-17

(45)

Published

2012-08-20

(72)

Inventor

Zarytova Valentina FilippovnaLevina Asja SaulovnaShatskaja Natal'Ja VladislavovnaRepkova Marina NikolaevnaIsmagilov Zinfer RishatovichShikina Nadezhda Vasil'Evna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Khimicheskoj Biologii I Fundamental'Noj Meditsiny Sibirskogo Otdelenija Ran So Ran)

METHOD FOR MAKING NANOSIZED SYSTEM OF ANTIBIOTIC BLEOMYCIN DELIVERY INTO MAMMAL CELLS Russian patent published in 2012 - IPC A61K47/02 A61K31/7064 A61P31/04 A61J3/00 B82B3/00 B82Y5/00

Abstract RU 2458705 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for making the nanosized antibiotic bleomycin delivery in mammal cells. The declared method consists in preparing a suspension containing TiO₂ nanoparticles sized 3-5 nm of the concentration of 1-25 mg/ml, exposing it to ultrasound and mixed with the antibiotic bleomycin. The TiO₂: antibiotic relation makes 1: (0.01-2). Then the prepared mixture is incubated in 0.1-0.5 M NaCl solution at room temperature in through mixing for min. 30 minutes.

EFFECT: technical effect of the declared invention consists in the simplified and shorter-term method for making the effective system of antibiotic bleomycin delivery into eukariotic cells, and also reducing a dose of the antibiotic having a toxic effect on a body.

4 dwg, 10 ex

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RU 2 458 705 C1

Authors

Zarytova Valentina Filippovna

Levina Asja Saulovna

Shatskaja Natal'Ja Vladislavovna

Repkova Marina Nikolaevna

Ismagilov Zinfer Rishatovich

Shikina Nadezhda Vasil'Evna

Dates

2012-08-20—Published

2011-06-17—Filed