FIELD: medicine.
SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, obstetrics and gynecology. Method includes simulating gestational toxicosis by intraperitoneal administration of N-nitro-L-arginine methyl ester at a dose of 25 mg/kg/day for 7 days to a laboratory rat on the 13-14th day of pregnancy. Simultaneously, against the background of the simulation, intragastric administration of taurine at a dose of 260 mg/kg once a day is carried out.
EFFECT: method leads to an increase in the perfusion of the placenta, providing correction of gestational toxicosis in the experiment.
1 cl, 1 ex
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Authors
Dates
2018-11-15—Published
2017-03-21—Filed