METHOD OF CORRECTION OF EXPERIMENTAL GESTATIONAL TOXICOSIS BY TAURINE ADMINISTRATION Russian patent published in 2018 - IPC G09B23/28 A61K31/195 A61P15/06 

Abstract RU 2672475 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, obstetrics and gynecology. Method includes simulating gestational toxicosis by intraperitoneal administration of N-nitro-L-arginine methyl ester at a dose of 25 mg/kg/day for 7 days to a laboratory rat on the 13-14th day of pregnancy. Simultaneously, against the background of the simulation, intragastric administration of taurine at a dose of 260 mg/kg once a day is carried out.

EFFECT: method leads to an increase in the perfusion of the placenta, providing correction of gestational toxicosis in the experiment.

1 cl, 1 ex

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Authors

Pokrovskij Mikhail Vladimirovich

Pokrovskaya Tatyana Grigorvna

Korokin Mikhail Viktorovich

Gureev Vladimir Vladimirovich

Gudyrev Oleg Sergeevich

Khadieva Taisiya Abdulkadirovna

Kostina Darya Aleksandrovna

Yakushev Vladimir Ivanovich

Dovgan Anton Pavlovich

Dates

2018-11-15Published

2017-03-21Filed