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IPC

G09B23/28(2006-01-01)

A61K31/44(2006-01-01)

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Application

2020117948, 2020-06-01

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Start date

2020-06-01

(22)

Actual filing date

2020-06-01

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Published

2020-11-10

(72)

Inventor

Gureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichYurakova Alesya ViktorovnaGolubev Ivan VladimirovichPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaChernomortseva Elena StanislavovnaKonovalova Elena AnatolevnaZatolokina Mariya AlekseevnaZhunusov Nikita Sergeevich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR CORRECTING ENDOTHELIAL DYSFUNCTION WITH SUBSTANCE OF 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN AN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2020 - IPC G09B23/28 A61K31/44

Abstract RU 2735903 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology and can be used for correction of endothelial dysfunction in pregnant women. Method of endothelial dysfunction correction in ADMA-like model of preeclampsia includes reproduction of preeclampsia model in Wistar rats by administering L-nitro-arginine-methyl ester 25 mg/kg intraperitoneally every 14 to 20 days of gestation, wherein for correction of endothelial dysfunction, 3-hydroxy-2-ethyl-6-methylpyridinium nicotinate is administered intraperitoneally in dosage 260 mg/kg from 14 to 20 days of pregnancy.

EFFECT: invention provides pronounced endothelial dysfunction correction in the simulated pathology.

1 cl, 1 ex, 1 tbl

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RU 2 735 903 C1

Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Yurakova Alesya Viktorovna

Golubev Ivan Vladimirovich

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Chernomortseva Elena Stanislavovna

Konovalova Elena Anatolevna

Zatolokina Mariya Alekseevna

Zhunusov Nikita Sergeevich

Dates

2020-11-10—Published

2020-06-01—Filed