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2 555 533

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IPC

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

C12N5/10(2006-01-01)

C07K16/24(2006-01-01)

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Application

2013123638/10, 2013-05-23

(24)

Start date

2013-05-23

(22)

Actual filing date

2013-05-23

(45)

Published

2015-07-10

(72)

Inventor

Aliev Tejmur KantamirovichBalabashin Dmitrij SergeevichDolgikh Dmitrij AleksandrovichKirpichnikov Mikhail PetrovichPanina Anna AlekseevnaToporova Viktorija Aleksandrovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Obrazovanija Gosudarstvennyj Universitet Imeni M.V. Lomonosova"

RECOMBINED PLASMID DNA CODING CHIMERIC ANTIBODY AGAINST HUMAN TUMOUR NECROSIS FACTOR-ALPHA, EUKARYOTIC CELL LINE PRODUCING CHIMERIC ANTIBODY, AND METHOD OF CHIMERIC ANTIBODY OBTAINMENT Russian patent published in 2015 - IPC C12N15/13 C12N15/63 C12N5/10 C07K16/24

Abstract RU 2555533 C9

FIELD: biotechnologies.

SUBSTANCE: invention offers recombinant plasmid DNA coding a chimeric antibody against human tumour necrosis factor-alpha (TNF-alpha) based on pOptiVEC^TM-TOPO® plasmid. Invention refers to eukaryotic cell line as a producer of antibody to TNF-alpha, method of cell line obtainment by transfection of plasmid DNA according to the invention, and method of chimeric antibody obtainment for TNF-alpha by cultivation of cell line according to the invention.

EFFECT: increased synthesis level for antibodies against TNF-alpha by producer cells.

12 cl, 8 dwg, 1 tbl, 3 ex

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RU 2 555 533 C9

Authors

Aliev Tejmur Kantamirovich

Balabashin Dmitrij Sergeevich

Dolgikh Dmitrij Aleksandrovich

Kirpichnikov Mikhail Petrovich

Panina Anna Alekseevna

Toporova Viktorija Aleksandrovna

Dates

2015-07-10—Published

2013-05-23—Filed