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IPC

C12N15/13(2006-01-01)

C12N15/85(2006-01-01)

C12N5/10(2006-01-01)

C12N5/75(2010-01-01)

C07K16/24(2006-01-01)

(21) (22)

Application

2014109462/10, 2014-03-12

(24)

Start date

2014-03-12

(22)

Actual filing date

2014-03-12

(45)

Published

2015-07-20

(72)

Inventor

Ishchenko Aleksandr MitrofanovichKadykov Aleksandr LeonidovichKalinin Jurij TikhonovichPetrov Aleksandr VladimirovichPigareva Natal'Ja Vasil'EvnaSimbirtsev Andrej Semenovich

(73)

Holder

Otkrytoe Aktsionernoe Obshchestvo Import, Ehksport"

STRAIN OF CELLS OF CHINESE HAMSTER OVARIES - PRODUCER OF RECOMBINANT ANTIBODY AGAINST TUMOUR NECROSIS FACTOR ALPHA OF HUMAN BEING Russian patent published in 2015 - IPC C12N15/13 C12N15/85 C12N5/10 C12N5/75 C07K16/24

Abstract RU 2556816 C1

FIELD: biotechnologies.

SUBSTANCE: strain of cells of the Chinese hamster ovaries CHO-Inflix 20/5 is produced, transfected by vectors, expressing light and heavy chains of chimeric antibody against tumour necrosis factor alpha (TNF-α) of human being is produced. The strain is deposited into the Russian collection of cellular cultures under No. RKKK(P)760D.

EFFECT: invention allows to produce chimeric antibody with the specific efficiency no less than 33,5 picograms per cell a day.

4 dwg, 2 tbl, 4 ex

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RU 2 556 816 C1

Authors

Ishchenko Aleksandr Mitrofanovich

Kadykov Aleksandr Leonidovich

Kalinin Jurij Tikhonovich

Petrov Aleksandr Vladimirovich

Pigareva Natal'Ja Vasil'Evna

Simbirtsev Andrej Semenovich

Dates

2015-07-20—Published

2014-03-12—Filed