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2 569 899

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IPC

C07D491/18(2006-01-01)

(21) (22)

Application

2014151090/04, 2014-12-16

(24)

Start date

2014-12-16

(22)

Actual filing date

2014-12-16

(45)

Published

2015-12-10

(72)

Inventor

Maslivets Andrej NikolaevichStepanova Ekaterina Evgen'EvnaMakhmudov Ramiz Ragibovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"Obshchestvo S Ogranichennoj Otvetstvennost'Ju

METHOD OF PRODUCING 6-ARYL-2-(2-HYDROXYPHENYL)-7,15-DIOXA-2-AZATETRACYCLO[6.5.2.0.0]PENTADEC-5-ENE-3,4,14-TRIONES Russian patent published in 2015 - IPC C07D491/18

Abstract RU 2569899 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing novel separate bridge compounds of the class 7,15-dioxa-2-azatetracyclo[6,5,2,0^1.5,0^8.13]pentadecane of formula I , where Ar=Ph, C₆H₄CI-4 and C₆H₄OEt-4, and a method for production thereof, which includes boiling 3-aroyl-2-hydroxy-2-(2-oxocyclohexyl)pyrrolo[2,1-c][1,4]benzoxazine-1,4(2H)-diones in a medium of an inert aprotic solvent. The obtained 6-aryl-2-(2-hydroxyphenyl)-7,15-dioxa-2-azatetracyclo[6,5,2,0^1.5,0^8.13]pentadec-5-ene-3,4,14-triones exhibit anti-nociceptive activity and can also be used as raw products for synthesis of novel heterocyclic systems and in pharmacology.

EFFECT: improved method.

3 cl, 1 tbl, 4 ex

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RU 2 569 899 C1

Authors

Maslivets Andrej Nikolaevich

Stepanova Ekaterina Evgen'Evna

Makhmudov Ramiz Ragibovich

Dates

2015-12-10—Published

2014-12-16—Filed