FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 2-(4-hydroxyphenyl)ethanol (p-thyrozol), having a marked stimulating effect, immunomodulating and cardioprotective activity, anticarcinogenic and anti-inflammatory properties. The method includes nitrating 2-phenylethanol, reducing 2-(4-nitrophehyl)nitroethanol and nitrating 2-(4-aminophenyl)ethanol with subsequent hydrolysis of the diazo-compound. Synthesis and hydrolysis of the diazo-compound is carried out in the presence of n-toluene sulphonic acid with molar ratio 2-(4-aminophenyl)ethanol:n-toluene sulphonic acid = 1.0:2.1-3.0.
EFFECT: method enables to obtain an end product of high quality from affordable material without using hard-to-get and expensive reagents, as well as hazardous production processes.
2 tbl, 15 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCING 4-OXOALKANE-1,1,2,2-TETRACARBONITRILES | 2015 |
|
RU2577537C1 |
| METHOD FOR MAKING 2-AMINO-4-ARYL-6-HEXYL-7-HYDROXY-4H-CHROMEN-3-CARBONITRILES | 2022 |
|
RU2802631C1 |
| PIPERAZINE COMPOUND INHIBITING PROSTAGLANDIN-D-SYNTHASE | 2010 |
|
RU2496778C2 |
| HISTONE DEACETYLASE INHIBITORS | 2008 |
|
RU2453536C2 |
| DERIVATIVES OF AMINOALKANOLS, METHOD OF OBTAINING AMINOALKANOLS AND THEIR APPLICATION | 2009 |
|
RU2515213C2 |
| 4H-BIS[1,2,5]OXADIAZOLO[3,4-b:3',4'-f]AZEPINE-8,9-DIAMINE DERIVATIVES AND METHOD FOR PRODUCTION THEREOF | 2012 |
|
RU2499799C2 |
| ALPHA-FORM OR BETA-FORM OF CRYSTAL OF ACETANILIDE DERIVATIVE | 2002 |
|
RU2303033C2 |
| METHOD OF PRODUCING 5,8-(BIS(METHYLENE(N,N-DIMETHYL-N-DODECYLAMMONIUM))-2-ETHYL-4H-[1,3]DIOXINO[4,5-C]PYRIDINIUM DICHLORIDE | 2019 |
|
RU2697848C1 |
| QUINOLONE DERIVATIVE FOR TREATMENT OF PATIENT WITH ENURESIS AND METHODS OF ITS SYNTHESIS | 1995 |
|
RU2149870C1 |
| DERIVATIVES OF 7-(2-AMINOETHYL)-BENZOTHIAZOLONE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHODS OF THEIR SYNTHESIS, DERIVATIVES OF N-[2-(4-HYDROXY-2-OXO-3H-1,3-BENZOTHIAZOLE-7-YL]-ETHYLAMIDE, PHARMACEUTICAL COMPOSITION SHOWING AGONISTIC ACTIVITY RELATIVE TO β-ADRENORECEPTORS | 1993 |
|
RU2114108C1 |
